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KMID : 0364219740170020051
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Korean Journal of Zoology
1974 Volume.17 No. 2 p.51 ~ p.56
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Spontaneous Morphological Transformation in Adenovirus Type 12 Induced Tumor Cells of Armenian and Chinese Hamsters
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Kang Yung-Sun
Hahn Sah-Sook
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Abstract
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Newborn Armenian and Chinese hamsters inoculated with adenovirus type 12 developed undifferentiated small cell tumors as early as 27 days after inoculation in the Chinese hamsters and within 30$\\sim$45 days in the Armenian hamsters. These tumors were transplantable and epithelial-like cell in morphology. Cultures of 6 tumors underwent spontaneous reversion to fibroblast-like morphology during the 14$\\sim$20 in vitro passages in the absence of chromosomal disturbances. While epithelial-like tumor derivatives were oncogenic and positive for the T-antigen, fibroblast-like revertants were non-oncogenic and negative for the T-antigen. Two other tumor derivatives reverted to fibroblast-like forms, immediately following exposure to SV40. These lacked the adenovirus T-antigen but were positive for the SV40 T-antigen and formed sarcomas in animals.
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KEYWORD
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